Investigating how a brain receptor affects inflammation and behavior
Official title: Neuroinflammation, Neuronal IL-1R1, and Behavior
Funded at Florida Atlantic University · NIH-10817931 · Data updated 2026-11-12
This study is looking at a brain receptor called IL-1R1 to see how it affects inflammation in the brain and how that might influence behavior and mental health, with the hope of finding new ways to help people with mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $331,903 |
| NIH project number | 5R01NS116914-05 |
| Project ID | NIH-10817931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals experiencing mental health disorders or neurodegenerative diseases associated with neuroinflammation.
✕Less likely to help
Patients with conditions unrelated to neuroinflammation or those not experiencing any psychiatric or neurological symptoms may not benefit from this research.
What this research studies
This research explores the role of a specific brain receptor, IL-1R1, in neuroinflammation and its impact on behavior and mental health. The study aims to map the distribution of this receptor in the brain and understand how it influences neuronal activity and connectivity in the context of neuroinflammation. By examining the relationship between IL-1R1 and behavioral deficits, the research seeks to uncover the underlying mechanisms that contribute to various central nervous system disorders. Patients may benefit from insights that could lead to new therapeutic approaches for mental health conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for mental health disorders linked to neuroinflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuroinflammation in mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Quan, Ning — Florida Atlantic University
- Study coordinator: Quan, Ning
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.