Investigating gut health and lung injury in trauma patients
Official title: BLRD Research Career Scientist Award Application
Funded at James a. Haley VA Medical Center · NIH-11105872 · Data updated 2026-11-12
This study is looking at how inflammation from trauma can hurt gut health and lead to lung problems in soldiers and veterans, with the goal of finding better ways to treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | April 1, 2018 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK6BX004210-08 |
| Project ID | NIH-11105872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are trauma patients, particularly soldiers and veterans, who are experiencing complications related to gut and lung health.
✕Less likely to help
Patients with non-trauma-related conditions or those not experiencing gut or lung complications may not benefit from this research.
What this research studies
This research focuses on understanding how trauma-induced inflammation affects gut health and contributes to lung injury in soldiers and veterans. It aims to explore the mechanisms behind gut barrier dysfunction, known as 'leaky gut', which can lead to serious complications after trauma. The study will utilize various models to analyze the molecular pathways involved and assess potential therapeutic strategies to improve gut barrier integrity and reduce lung injury. By examining these connections, the research seeks to provide insights that could lead to better treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for trauma patients, potentially reducing complications like lung injury.
How similar studies have gone: While the specific approach may be novel, previous research has indicated that addressing gut health can significantly impact recovery outcomes in trauma patients.
Where this research is happening
-
James a. Haley VA Medical Center
Tampa, United States Active
Researchers
- Principal investigator: Wu, Mack H — James a. Haley VA Medical Center
- Study coordinator: Wu, Mack H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.