Investigating genetics in patients with severe depression treated with ECT
1/2 Genetics at an extreme: an efficient genomic study of individuals with clinically severe major depression receiving ECT
This study is looking at how genes might affect how well people with severe depression respond to electroconvulsive therapy (ECT), so we can better understand who might benefit most from this treatment and improve their chances of feeling better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10462540 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors associated with severe major depressive disorder (MDD) in individuals receiving electroconvulsive therapy (ECT). By analyzing the genetic makeup of these patients, the study aims to identify variations that may indicate which patients are most likely to benefit from ECT and how they might respond to the treatment. This approach seeks to improve treatment outcomes and reduce the trial-and-error process often faced by patients with severe depression. The study involves collaboration among global investigators to enhance the power of genetic analysis in this severely affected population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with severe major depressive disorder who are receiving or are candidates for electroconvulsive therapy.
Not a fit: Patients with mild depression or those who are not undergoing ECT may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with severe depression.
How similar studies have performed: Previous studies have shown promise in identifying genetic factors related to depression, but this specific approach focusing on severe cases treated with ECT is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Zandi, Peter P. — Johns Hopkins University
- Study coordinator: Zandi, Peter P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.