Investigating genetic variations linked to mental health traits
Official title: Population-level and mechanistic dissection of 17q21 structural variant association with psychiatric traits
Funded at University of Pennsylvania · NIH-10615663 · Data updated 2026-11-12
This study is looking at how certain genes on chromosome 17 might affect mental health, helping us understand how your unique genetics could influence your psychiatric traits and disorders, which could lead to more personalized treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $564,953 |
| NIH project number | 5R01MH123922-05 |
| Project ID | NIH-10615663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of psychiatric disorders or those experiencing mental health challenges.
✕Less likely to help
Patients with no genetic predisposition to psychiatric disorders or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research explores how specific genetic variations on chromosome 17 are associated with various psychiatric traits and disorders. By analyzing a large cohort of individuals, the study aims to connect these genetic markers to observable mental health outcomes and understand the biological mechanisms behind them. Patients may benefit from insights into how their genetic makeup influences their mental health, potentially leading to more personalized treatment approaches. The research employs advanced genetic analysis techniques to dissect the complex relationships between genes and psychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of mental health disorders based on genetic predispositions.
How similar studies have gone: Previous research has shown success in linking genetic variations to psychiatric traits, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Gandal, Michael — University of Pennsylvania
- Study coordinator: Gandal, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.