Investigating genetic factors that influence psychiatric disorders through RNA variations
Isoform-level probabilistic transcriptome-wide association to undercover neurogenetic mechanisms underlying complex psychiatric traits
This study is looking at how different genetic variations might affect mental health, especially for people with conditions like autism and schizophrenia, to help find better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10771303 on NIH RePORTER |
What this research studies
This research aims to uncover the genetic mechanisms behind psychiatric disorders by analyzing how different RNA transcript variations are linked to mental health conditions. By integrating large-scale genetic data with tissue-specific gene expression information, the study will identify specific RNA isoforms that may contribute to the risk of developing psychiatric diseases. Patients may benefit from a better understanding of the genetic factors that influence their mental health, potentially leading to more targeted treatments. The research will focus on individuals with psychiatric disorders, particularly those affected by conditions like autism and schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with psychiatric disorders such as autism or schizophrenia.
Not a fit: Patients without any psychiatric disorders or those who are not affected by the genetic variations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for psychiatric disorders based on genetic insights.
How similar studies have performed: Other research has shown promise in using genetic approaches to understand psychiatric disorders, making this a continuation of a growing field rather than a completely novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gandal, Michael — University of Pennsylvania
- Study coordinator: Gandal, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.