Investigating genetic factors that increase leukemia risk in children with Down syndrome
Official title: Genetic determinants of lymphocyte traits and risk of acute lymphoblastic leukemia in children with Down syndrome
Funded at University of Southern California · NIH-10700064 · Data updated 2026-11-12
This study is looking at how certain genes might affect the chances of children with Down syndrome getting acute lymphoblastic leukemia (ALL), so we can find ways to better predict and prevent this risk for those kids.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $123,750 |
| NIH project number | 5R03HD109778-02 |
| Project ID | NIH-10700064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children with Down syndrome, particularly those under the age of 11, who may be at risk for developing acute lymphoblastic leukemia.
✕Less likely to help
Patients without Down syndrome or those who are older than 11 years may not benefit from this research.
What this research studies
This research focuses on understanding how genetic variations influence the risk of acute lymphoblastic leukemia (ALL) in children with Down syndrome. By analyzing genetic data from children with Down syndrome who have developed ALL and comparing it to those who have not, the study aims to identify specific genetic traits that may contribute to this increased risk. The researchers will utilize advanced techniques such as whole-genome sequencing to uncover these genetic determinants and their potential impact on treatment outcomes. This could lead to better prediction models for prevention and early intervention strategies for children at risk.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for children with Down syndrome, potentially reducing the incidence of leukemia.
How similar studies have gone: Previous research has shown promising results in identifying genetic risk factors for leukemia in children, suggesting that this approach could yield valuable insights for children with Down syndrome as well.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: De Smith, Adam — University of Southern California
- Study coordinator: De Smith, Adam
Related research
Other NIH-funded projects on the same topics.
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Preventing fatal infections in children with Down syndrome during ALL treatment
Aimed at reducing deadly infections in children with Down syndrome undergoing chemotherapy for acute lymphoblastic leukemia by finding biomarkers to tailor treatment and supportive care.
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Preventing deadly infections in children with Down syndrome during leukemia treatment
This project looks for blood markers that can identify children with Down syndrome and acute lymphoblastic leukemia who are at high risk for life-threatening infections so doctors can offer extra protection early.
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Investigating the link between Down syndrome and acute lymphoblastic leukemia in children
This study is looking into why kids with Down syndrome are more likely to get a type of blood cancer called acute lymphoblastic leukemia, and it hopes to find out how their genes play a role in this so that we can help keep them healthier.
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Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
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Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
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Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.