Investigating genetic factors that increase leukemia risk in children with Down syndrome
Genetic determinants of lymphocyte traits and risk of acute lymphoblastic leukemia in children with Down syndrome
This study is looking at how certain genes might affect the chances of children with Down syndrome getting acute lymphoblastic leukemia (ALL), so we can find ways to better predict and prevent this risk for those kids.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10700064 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variations influence the risk of acute lymphoblastic leukemia (ALL) in children with Down syndrome. By analyzing genetic data from children with Down syndrome who have developed ALL and comparing it to those who have not, the study aims to identify specific genetic traits that may contribute to this increased risk. The researchers will utilize advanced techniques such as whole-genome sequencing to uncover these genetic determinants and their potential impact on treatment outcomes. This could lead to better prediction models for prevention and early intervention strategies for children at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with Down syndrome, particularly those under the age of 11, who may be at risk for developing acute lymphoblastic leukemia.
Not a fit: Patients without Down syndrome or those who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for children with Down syndrome, potentially reducing the incidence of leukemia.
How similar studies have performed: Previous research has shown promising results in identifying genetic risk factors for leukemia in children, suggesting that this approach could yield valuable insights for children with Down syndrome as well.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: De Smith, Adam — University of Southern California
- Study coordinator: De Smith, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.