Investigating genes that link lipid metabolism to heart diseases
Official title: From genetic association to function: pleiotropic novel genes and variants linking lipid metabolism and cardiovascular diseases
Funded at University of Pennsylvania · NIH-11032841 · Data updated 2026-11-12
This study is looking at how our genes affect fat levels in the blood and how that might lead to heart problems, with the hope of finding new ways to treat these issues for people who currently have limited options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,000,576 |
| NIH project number | 5R35HL172107-02 |
| Project ID | NIH-11032841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiovascular diseases or those diagnosed with conditions like atherosclerosis or aortic stenosis.
✕Less likely to help
Patients with cardiovascular diseases that are not linked to lipid metabolism may not receive benefit from this research.
What this research studies
This research explores how certain genes and genetic variants influence lipid metabolism and contribute to various cardiovascular diseases. By analyzing human genetic data, the study aims to identify causal genes and the biological mechanisms that lead to increased risk or protection from these diseases. The focus is on understanding the relationship between plasma lipid traits and major cardiovascular conditions, such as atherosclerosis and aortic stenosis, with the goal of uncovering new therapeutic targets. Patients may benefit from insights that could lead to novel treatments for cardiovascular diseases that currently lack effective medical therapies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cardiovascular diseases linked to lipid metabolism.
How similar studies have gone: Previous research has shown promise in linking genetic factors to cardiovascular diseases, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Rader, Daniel James — University of Pennsylvania
- Study coordinator: Rader, Daniel James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.