Investigating gene isoforms using advanced RNA sequencing techniques
Official title: Advanced quantitative analyses of long-read RNA-seq at the bulk and single-cell dimensions
Funded at University of Michigan at Ann Arbor · NIH-11089059 · Data updated 2026-11-12
This study is exploring how different versions of genes work in conditions like cancer, using advanced technology to better understand these variations, which could help us find new ways to treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $424,264 |
| NIH project number | 1R35GM158052-01 |
| Project ID | NIH-11089059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with cancers or genetic conditions where gene expression plays a critical role.
✕Less likely to help
Patients with conditions unrelated to gene isoforms or those not affected by genetic variations may not benefit from this research.
What this research studies
This research focuses on using long-read RNA sequencing to analyze gene isoforms, which are variations of genes that can play significant roles in conditions like cancer and developmental processes. The team at the University of Michigan has developed innovative bioinformatics tools to identify and quantify these complex gene variations, allowing for deeper insights into their functions. By examining both bulk and single-cell RNA data, the research aims to uncover important differences in gene expression that could lead to new understandings of diseases and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with cancer and other genetic disorders.
How similar studies have gone: Previous research using long-read RNA sequencing has shown promising results in understanding gene isoforms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Au, Kin Fai — University of Michigan at Ann Arbor
- Study coordinator: Au, Kin Fai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.