Investigating gene interactions using advanced CRISPR technology in mouse models
Orthogonal CRISPR GEMMs
This study is looking at how different genes work together in mice to help us understand complex diseases better, using a new technology that allows us to explore many genes at once, which could lead to new ways to tackle health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11026386 on NIH RePORTER |
What this research studies
This research aims to transform how we study human genes by moving beyond the traditional one-gene-at-a-time approach. It utilizes a high-throughput CRISPR technology to explore multiple gene interactions simultaneously in mouse models, which can provide insights into complex diseases. By targeting specific genes involved in particular pathways, the research seeks to uncover how these genes work together in a living organism. The ultimate goal is to create a versatile toolset that can be applied to various biological questions and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases where gene interactions play a significant role.
Not a fit: Patients with conditions that are not influenced by genetic interactions or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic interactions that contribute to diseases, potentially informing new treatment strategies.
How similar studies have performed: Other research has shown promise in using CRISPR technology for gene editing, but this multi-mutation approach in organismal models is novel and untested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Mcmanus, Michael T — University of California, San Francisco
- Study coordinator: Mcmanus, Michael T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.