Investigating factors affecting recovery in survivors of Acute Respiratory Distress Syndrome
Official title: Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors
Funded at Columbia University Health Sciences · NIH-10917148 · Data updated 2026-11-12
This study is looking at why some people who survived severe lung issues from COVID-19 still feel weak and have trouble recovering, and it’s for ARDS survivors who want to help find ways to improve their recovery over the next year.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $712,421 |
| NIH project number | 5R01HL164777-02 |
| Project ID | NIH-10917148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have survived Acute Respiratory Distress Syndrome.
✕Less likely to help
Patients who have not experienced ARDS or those with pre-existing severe muscle or respiratory conditions may not benefit from this research.
What this research studies
This research focuses on understanding the reasons behind persistent muscle weakness and poor recovery in survivors of Acute Respiratory Distress Syndrome (ARDS), particularly following COVID-19. The study will enroll 345 ARDS survivors and follow them for 12 months to assess inflammation, hormonal levels, and muscle function. By identifying specific biological factors that contribute to ongoing disability, the research aims to uncover potential treatment targets to improve recovery outcomes for these patients. Participants will undergo evaluations three months after hospital discharge to determine their recovery status.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve muscle strength and overall recovery for ARDS survivors.
How similar studies have gone: While there is ongoing research into ARDS recovery, this specific approach targeting multi-systemic dysregulation in ARDS survivors is relatively novel.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Baldwin, Matthew R — Columbia University Health Sciences
- Study coordinator: Baldwin, Matthew R
Related research
Other NIH-funded projects on the same topics.
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Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
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Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.