Investigating factors affecting recovery in survivors of Acute Respiratory Distress Syndrome
Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors
This study is looking at why some people who survived severe lung issues from COVID-19 still feel weak and have trouble recovering, and it’s for ARDS survivors who want to help find ways to improve their recovery over the next year.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10917148 on NIH RePORTER |
What this research studies
This research focuses on understanding the reasons behind persistent muscle weakness and poor recovery in survivors of Acute Respiratory Distress Syndrome (ARDS), particularly following COVID-19. The study will enroll 345 ARDS survivors and follow them for 12 months to assess inflammation, hormonal levels, and muscle function. By identifying specific biological factors that contribute to ongoing disability, the research aims to uncover potential treatment targets to improve recovery outcomes for these patients. Participants will undergo evaluations three months after hospital discharge to determine their recovery status.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have survived Acute Respiratory Distress Syndrome.
Not a fit: Patients who have not experienced ARDS or those with pre-existing severe muscle or respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve muscle strength and overall recovery for ARDS survivors.
How similar studies have performed: While there is ongoing research into ARDS recovery, this specific approach targeting multi-systemic dysregulation in ARDS survivors is relatively novel.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Baldwin, Matthew R — Columbia University Health Sciences
- Study coordinator: Baldwin, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.