Investigating enzymes that cause cell death in kidney and cancer cells
BLRD Research Career Scientist Award Application
This study is looking at how certain enzymes can cause cell death after injuries to tissues, like those from drugs or diseases, and aims to find ways to protect kidney and cancer cells from damage, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project ID | NIH-10950293 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific enzymes, known as DNases, contribute to cell death following tissue injuries, such as those caused by drugs or diseases. The team aims to identify the endonucleases involved in DNA fragmentation in kidney cells during acute renal failure and in cancer cells during treatment with anticancer drugs. By exploring the mechanisms of these enzymes, the researchers hope to develop non-toxic inhibitors that could protect cells from death, potentially leading to new treatments for kidney injuries and cancer. Patients may benefit from advancements in therapies that mitigate cell damage during critical health events.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing acute kidney failure or those undergoing treatment for specific types of cancer.
Not a fit: Patients with chronic kidney disease or those not undergoing cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new protective treatments for patients suffering from acute kidney injuries and certain cancers.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for cell protection, indicating potential for success in this novel approach.
Where this research is happening
North Little Rock, United States
- Central Arkansas Veterans Hlthcare Sys — North Little Rock, United States (Active)
Researchers
- Principal investigator: Basnakian, Alexei G — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Basnakian, Alexei G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.