Investigating DNA repair mechanisms in cancer treatment
Mesocale And Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)
This study is looking at how cancer cells with BRCA mutations repair their DNA and how this affects the immune system, with the goal of finding better ways to help patients with advanced cancer, especially those using treatments like PARP inhibitors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10894650 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA repair complexes function in cancer cells, particularly those with BRCA mutations. By exploring the relationship between DNA damage and the body's immune response, the study aims to identify new strategies to overcome resistance to current cancer therapies. Patients with advanced cancer, especially those with BRCA mutations, may benefit from insights gained about how to enhance the effectiveness of treatments like PARP inhibitors. The research employs advanced technologies to analyze the DNA damage response and its implications for cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cancer, particularly those with BRCA1 or BRCA2 mutations.
Not a fit: Patients without BRCA mutations or those with early-stage cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments that are more effective against tumors with BRCA mutations.
How similar studies have performed: Previous research has shown promise in understanding DNA repair mechanisms and their role in cancer treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Tainer, John a. — University of Tx Md Anderson Can Ctr
- Study coordinator: Tainer, John a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.