Investigating critical transitions in cancer development and progression
Official title: Single Cell Analysis Core
Funded at University of California-Irvine · NIH-11016821 · Data updated 2026-11-12
This study is looking at how changes in cells, not just their genes, can affect the start and growth of cancer, and it aims to create a special lab that helps researchers understand how different types of cells in tumors work together, so they can better predict how cancer behaves and spreads.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $272,963 |
| NIH project number | 1P01CA288662-01A1 |
| Project ID | NIH-11016821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with advanced cancer who are interested in contributing to innovative cancer research.
✕Less likely to help
Patients with early-stage cancer or benign conditions may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how certain critical transitions, particularly non-genetic changes, influence the initiation and progression of cancer. It aims to develop a Single Cell Analysis Core that will analyze complex omics data to provide insights into various cell types and their interactions within tumors. By employing high throughput multi-omics technologies, the project will offer computational support for experimental design, data analysis, and integration of findings across different cancer research projects. This collaborative approach seeks to refine experimental strategies and develop models that can predict cancer behavior and metastasis.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer dynamics, potentially informing more effective treatment strategies.
How similar studies have gone: Previous research has shown promise in using multi-omics approaches to understand cancer, suggesting that this methodology could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Wu, Jie — University of California-Irvine
- Study coordinator: Wu, Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.