Investigating complications in patients after blood stem cell transplants
Epidemiology and Biomarkers in Transplant Associated Thrombotic Microangiopathy (TA-TMA): A Prospective Validation Cohort Study
This study is looking at ways to spot a serious condition called transplant-associated thrombotic microangiopathy (TA-TMA) early in kids who have had a stem cell transplant, so doctors can better help them recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11057692 on NIH RePORTER |
What this research studies
This research focuses on transplant-associated thrombotic microangiopathy (TA-TMA), a serious complication that can occur after allogeneic hematopoietic cell transplantation. The study aims to identify clinical risk factors and laboratory biomarkers that can help in the early detection and risk assessment of TA-TMA in pediatric patients. By using a prospective cohort approach, researchers will gather data to develop a dynamic risk prediction tool that could improve patient outcomes. This research is led by Dr. Ang Li at Baylor College of Medicine, who is dedicated to advancing patient-oriented care in hematology.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients who are undergoing or have recently undergone allogeneic hematopoietic cell transplantation.
Not a fit: Patients who have not undergone allogeneic hematopoietic cell transplantation or those with other unrelated hematologic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and management of TA-TMA, potentially reducing its severity and improving survival rates for affected patients.
How similar studies have performed: Previous research has identified risk factors for TA-TMA, but this study aims to validate these findings in a prospective cohort, making it a novel approach in this area.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Ang — Baylor College of Medicine
- Study coordinator: Li, Ang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.