Investigating calcium channels in brain cancer
Calcium Channels in Glioblastoma
This study is looking at how calcium signals in brain cancer cells, specifically glioblastoma, can affect how the cancer grows, and it aims to see if blocking certain calcium channels can help slow down the tumor and improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10910104 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, the most common and deadly brain tumor, by examining how calcium signaling affects cancer cell behavior. The study aims to understand the role of T-Type calcium channels in glioblastoma cells and their interactions with the tumor microenvironment. Researchers will use advanced mouse models to explore how blocking these calcium channels can inhibit tumor growth and improve treatment outcomes. By employing genomic and proteomic techniques, the research seeks to uncover the mechanisms by which calcium signaling influences cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma who may benefit from novel treatment approaches targeting calcium channels.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating glioblastoma, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promising results in targeting calcium signaling pathways in various cancers, suggesting potential for success in this novel approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Abounader, Roger — University of Virginia
- Study coordinator: Abounader, Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.