Investigating brain tissue from autopsies to understand aging and dementia in Down syndrome.
Core F: Neuropathology Core
This study is looking at brain tissue from people with Down syndrome who have passed away to learn more about how aging and dementia affect them, helping us connect what we see in living brains with what we find after death.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10667587 on NIH RePORTER |
What this research studies
This research focuses on collecting and analyzing brain tissue from autopsies of individuals with Down syndrome to better understand the effects of aging and dementia. The Neuropathology Core will provide detailed neuropathology diagnoses and perform advanced imaging techniques on post-mortem brain samples. By creating a network for brain autopsies and sharing data, the research aims to bridge the gap between living brain imaging and post-mortem findings, ultimately enhancing our understanding of neurological conditions associated with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who are enrolled in the ABC-DS study and have undergone brain autopsy.
Not a fit: Patients who are not diagnosed with Down syndrome or who do not have a brain autopsy performed will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for aging and dementia in individuals with Down syndrome.
How similar studies have performed: Similar research approaches have shown promise in understanding neurological conditions through post-mortem studies, indicating potential for success in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Head, Elizabeth — University of Pittsburgh at Pittsburgh
- Study coordinator: Head, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.