Investigating brain proteins related to mental health using advanced genetic techniques.
In situ proteomics for brain using genetically encoded probes.
This study is looking at how certain proteins in the brain work together in people with bipolar disorder by using special tools in mice, which could help us better understand the biology behind mental health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10707181 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex protein networks in the brain that are associated with mental health disorders, particularly bipolar disorder. By using genetically encoded probes in mice, the study aims to create a more accurate representation of how these proteins interact in a living brain environment. The approach involves tagging specific proteins and observing their interactions in real-time, which could lead to insights into the biological mechanisms underlying psychiatric conditions. This innovative method seeks to bridge the gap between laboratory findings and physiological realities, potentially improving our understanding of mental illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diagnosis of bipolar disorder or related psychiatric conditions.
Not a fit: Patients with non-psychiatric conditions or those not diagnosed with mental health disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic targets for treating mental health disorders.
How similar studies have performed: While this approach is innovative, similar methodologies in other areas of biomedical research have shown promise, suggesting potential for success in this novel application.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Hamilton, Bruce a — University of California, San Diego
- Study coordinator: Hamilton, Bruce a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.