Investigating brain energy processes in early psychosis
Brain bioenergetics and slow wave activity in first episode psychosis
This study is looking at how the brain's energy use changes in people who are just starting to experience psychosis, like schizophrenia, to find new ways to help them feel better, especially by looking at how sleep affects brain energy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10898072 on NIH RePORTER |
What this research studies
This research focuses on understanding how energy metabolism in the brain is affected during the early stages of psychosis, particularly schizophrenia. It aims to identify new biological mechanisms that contribute to the disorder by examining the role of creatine kinase and its impact on brain energy levels during neuronal activation. By studying the relationship between sleep patterns, specifically slow wave sleep, and brain energy homeostasis, the research seeks to uncover potential new treatment strategies for individuals experiencing their first episode of psychosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing their first episode of psychosis, including those diagnosed with schizophrenia or bipolar disorder.
Not a fit: Patients with chronic psychotic disorders who are not in the early stages of their illness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatment approaches that improve outcomes for patients with early-stage psychosis.
How similar studies have performed: While there is emerging evidence regarding brain energy abnormalities in psychotic disorders, this specific approach focusing on creatine kinase during neuronal activation is relatively novel and has not been extensively tested.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Yuksel, Abdullah Cagri — Mclean Hospital
- Study coordinator: Yuksel, Abdullah Cagri
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.