Investigating brain connectivity differences in autism spectrum disorders
Testing the Bottom-Up vs Top-Down Imbalance Hypothesis of ASD
This study is looking at how the brains of people with autism work differently from those without autism, using special imaging tools to find out what might be causing some of the challenges they face, which could help improve treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10431883 on NIH RePORTER |
What this research studies
This research explores how brain connectivity in individuals with autism spectrum disorders (ASD) differs from typical patterns. By using advanced imaging techniques like magnetoencephalography (MEG), the study aims to identify specific abnormalities in brain function that may contribute to the symptoms of ASD. The researchers will analyze various frequency bands of brain activity to construct a clearer model of how these connectivity issues manifest. This could lead to a better understanding of the neural basis of ASD and inform future treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorders, across various age groups.
Not a fit: Patients without a diagnosis of autism spectrum disorders or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted interventions for individuals with autism spectrum disorders.
How similar studies have performed: Previous research has shown varying results regarding brain connectivity in ASD, indicating that this area of study is still evolving and holds potential for new insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kenet, Tal — Massachusetts General Hospital
- Study coordinator: Kenet, Tal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.