Investigating blood vessel damage in adults after stem cell transplants
MIDAS: MIcroangiopathy, endothelial Damage in Adults undergoing Stem cell transplantation
This study is looking at a serious condition called HCT-TMA that can happen to adults after they receive a stem cell transplant, especially older adults, to find out what makes it more likely to occur and how it affects patients, with the hope of improving care and treatment for those going through this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10894946 on NIH RePORTER |
What this research studies
This research focuses on understanding a serious complication called hematopoietic cell transplant-associated thrombotic microangiopathy (HCT-TMA) that can occur in adults following stem cell transplantation. The study aims to identify risk factors and outcomes associated with HCT-TMA, particularly in older adults who may be more susceptible to this condition. By establishing a prospective cohort of patients, the research will gather data on the incidence and severity of HCT-TMA, which is often underdiagnosed due to a lack of routine screening. The findings could lead to improved monitoring and treatment strategies for patients undergoing stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are undergoing or have recently undergone stem cell transplantation.
Not a fit: Patients who are not undergoing stem cell transplantation or who are younger than 18 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of HCT-TMA, potentially reducing mortality rates and improving outcomes for patients undergoing stem cell transplants.
How similar studies have performed: While there has been significant research on HCT-TMA in children, this study represents a novel approach as there are currently no prospective studies focusing on adults.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Vasu, Sumithira — Ohio State University
- Study coordinator: Vasu, Sumithira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.