Investigating autoantibodies related to muscle repair in myositis
Official title: Autoantibodies to membrane repair proteins in myositis
Funded at Ohio State University · NIH-10945787 · Data updated 2026-11-12
This study is looking at how certain proteins that help repair muscle cells might affect the muscle weakness and inflammation seen in idiopathic inflammatory myopathies, with the hope of finding better treatments for people dealing with these challenging conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 24, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $463,039 |
| NIH project number | 1R01AR084518-01 |
| Project ID | NIH-10945787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with idiopathic inflammatory myopathies who experience muscle weakness and inflammation.
✕Less likely to help
Patients with myositis who do not have detectable autoantibodies or those with other unrelated muscle disorders may not benefit from this research.
What this research studies
This research focuses on idiopathic inflammatory myopathies (IIM), a group of disorders that cause muscle weakness and inflammation. The study aims to understand the role of autoantibodies to membrane repair proteins in the progression of myositis. By using advanced animal models, researchers will explore how defects in muscle cell membrane repair contribute to muscle inflammation and injury. The findings could lead to better-targeted treatments for patients suffering from these debilitating conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with myositis, potentially reducing muscle inflammation and enhancing recovery.
How similar studies have gone: Previous studies have shown promising results in understanding the role of membrane repair in muscle diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Jarjour, Wael N — Ohio State University
- Study coordinator: Jarjour, Wael N
Related research
Other NIH-funded projects on the same topics.
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Myositis-ILD Risk Prediction: How ILD Progresses in Myositis Patients
A study to build better tools that predict how lung disease linked to myositis will behave in diverse patients.
-
Autoantibodies and membrane repair in myositis
A blood and tissue study seeks to understand how immune reactions against muscle repair proteins contribute to inflammatory myositis, with the goal of guiding better treatments for people with this condition.
-
Why chikungunya causes long-lasting joint and muscle pain
This work looks at how chikungunya virus can linger in joint and muscle cells and keep causing pain for people who had the infection.
-
Autoantibodies against muscle membrane repair proteins in myositis
This work looks at whether people with myositis have antibodies that attack proteins that fix damaged muscle cell membranes and how that may cause muscle inflammation and weakness.
-
Predicting lung disease outcomes in people with myositis
This project combines medical information and genetic markers to predict which people with myositis will have worsening interstitial lung disease.
-
Cancer risk in inflammatory muscle disease (myositis)
This project looks for signs in people with idiopathic inflammatory myopathies that show whether they have or might develop cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.