Investigating a protein's role in stroke treatment
Transient Receptor Potential Melastatin 2 (TRPM2) in Ischemic Stroke
This study is looking at a protein called TRPM2 to see how it affects brain damage during a stroke, with the hope of finding new treatments that could help people recover better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10993195 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the TRPM2 protein in ischemic stroke, a condition that leads to significant disability and death. The study aims to explore how TRPM2 contributes to the injury process during a stroke and whether it can be targeted for new therapies. By using both classical and clinically relevant animal models, the researchers hope to identify effective treatment strategies that could translate into better outcomes for stroke patients. The approach involves examining the complex interactions of various cell types and signaling pathways involved in stroke pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of ischemic stroke or those who have experienced a stroke.
Not a fit: Patients with hemorrhagic stroke or those with conditions unrelated to ischemic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve recovery and outcomes for stroke patients.
How similar studies have performed: While there have been many studies on stroke therapies, this approach targeting TRPM2 is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Yue, Lixia — University of Connecticut Sch of Med/dnt
- Study coordinator: Yue, Lixia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.