Investigating a new therapy for atherosclerosis using selective estrogen complexes.
Atherosclerosis Intervention with Novel Tissue Selective Estrogen Complex Therapy
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10694230
This study is testing a new treatment that combines estrogen with another medication to help women going through menopause feel better and stay healthy, without some of the risks linked to traditional hormone therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10694230 on ClinicalTrials.gov |
What this research studies
This research focuses on a novel therapy that combines estrogen with a selective estrogen receptor modulator to treat menopausal symptoms and reduce risks associated with traditional hormone therapies. The approach aims to provide benefits without the need for progestogen, which can pose health risks. By conducting phase 3 randomized controlled trials, the study evaluates the safety and efficacy of this new treatment in women experiencing menopause. Patients may be monitored for various health outcomes, including cardiovascular health and bone density.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women experiencing menopausal symptoms who are at risk for atherosclerosis.
Not a fit: Patients who are premenopausal or those who do not have menopausal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a safer and more effective treatment option for menopausal women, potentially reducing the risk of atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results with selective estrogen receptor modulators, indicating potential for success with this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HODIS, HOWARD NEIL — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: HODIS, HOWARD NEIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease, Breast Cancer, Cardiovascular Diseases