Investigating a new target for treating Non-Alcoholic Fatty Liver Disease
AKR1a1 as a novel therapeutic target for Non-Alcoholic Fatty Liver Disease
This study is looking at how a protein called AKR1a1 affects fat in the liver for people with Non-Alcoholic Fatty Liver Disease (NAFLD), and it hopes to find new ways to help manage this condition using advanced techniques in animal models.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11010839 on NIH RePORTER |
What this research studies
This research focuses on Non-Alcoholic Fatty Liver Disease (NAFLD), a condition where fat accumulates in the liver without alcohol involvement. The study aims to explore the role of a protein called AKR1a1 in liver fat metabolism and its potential as a new treatment target. Researchers will use advanced techniques like CRISPR-Cas9 gene editing and small molecule inhibitors in animal models to understand how AKR1a1 affects liver health. By examining the biochemical pathways involved, the research seeks to uncover new therapeutic strategies for managing NAFLD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Non-Alcoholic Fatty Liver Disease.
Not a fit: Patients with liver disease caused by alcohol consumption or viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from Non-Alcoholic Fatty Liver Disease.
How similar studies have performed: While the specific approach of targeting AKR1a1 is novel, similar research has shown promise in exploring new therapeutic targets for liver diseases.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Venetos, Nicholas — Case Western Reserve University
- Study coordinator: Venetos, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.