Investigating a new protein's role in cell death and disease.
Regulation of cell death and disease by a novel membrane protein MADMAN.
This study is looking at a new protein called MADMAN that helps control a special kind of cell death linked to diseases like infections and cancer, and it aims to find out how this protein works with others to better understand how we might influence cell death in these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10695170 on NIH RePORTER |
What this research studies
This research focuses on understanding a newly identified membrane protein called MADMAN, which plays a crucial role in a specific type of cell death known as necroptosis. Necroptosis is different from traditional cell death processes and is linked to various diseases, including infections and cancers. The researchers will use advanced techniques, including CRISPR-Cas9, to explore how MADMAN interacts with other proteins to regulate this cell death pathway. By uncovering these mechanisms, the study aims to provide insights into how cell death can be manipulated in disease contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions related to necroptosis, including certain cancers and severe bacterial infections.
Not a fit: Patients with conditions unrelated to necroptosis or those who do not have a significant immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases associated with abnormal cell death, such as cancer and infections.
How similar studies have performed: While the specific role of MADMAN in necroptosis is novel, similar research has shown promise in understanding cell death pathways and their implications in various diseases.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Zhigao — University of South Florida
- Study coordinator: Wang, Zhigao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.