Investigating a new protein involved in lung blood vessel changes in pulmonary arterial hypertension.
Official title: Novel mechanism for eNAMPT secretion in PAH vascular remodeling
Funded at University of Florida · NIH-11088022 · Data updated 2026-11-12
This study is looking at a protein called eNAMPT to see how it affects inflammation and blood vessel changes in people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to treat this condition and help patients feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 21, 2023 |
| Project end | August 20, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,056 |
| NIH project number | 5F31AG082409-03 |
| Project ID | NIH-11088022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
✕Less likely to help
Patients with other forms of pulmonary hypertension not related to the mechanisms being studied may not benefit from this research.
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious condition that causes changes in the blood vessels of the lungs, leading to increased pressure and heart problems. The study aims to explore the role of a protein called eNAMPT, which is secreted by various cells and may contribute to inflammation and vascular remodeling in PAH. By understanding how eNAMPT functions and its effects on the body, researchers hope to identify new therapeutic strategies to treat this condition. Patients may benefit from insights that could lead to innovative treatments targeting this protein.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from pulmonary arterial hypertension.
How similar studies have gone: Previous research has shown promising results in targeting similar inflammatory pathways in other lung conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Rodriguez, Marisela — University of Florida
- Study coordinator: Rodriguez, Marisela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.