Investigating a new approach to diagnose and treat kidney injury during heart surgery
Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury
This study is looking at how a protein called NPM1 affects kidney damage during heart surgery, with the goal of finding new treatments to help protect patients at risk of kidney injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11121807 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called NPM1 contributes to kidney injury during ischemic events, particularly in patients undergoing cardiac surgery. By exploring the interactions between NPM1 and another protein, Bax, the team aims to develop new drugs that can prevent kidney cell death. The study employs advanced techniques such as x-ray crystallography and medicinal chemistry to design and test potential therapies. Patients at high risk for acute kidney injury will be the primary focus, as the findings could lead to significant improvements in their care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for cardiac surgery who are at high risk for acute kidney injury.
Not a fit: Patients with pre-existing chronic kidney disease or those not undergoing cardiac surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of kidney injury in patients undergoing cardiac surgery.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for kidney protection, suggesting a potential for success in this novel approach.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Borkan, Steven C. — Boston Medical Center
- Study coordinator: Borkan, Steven C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.