Investigating a medication to improve breathing in COPD patients with high blood pressure in the lungs
Effect of PDE5 inhibitor on respiratory symptoms in COPD complicated by pulmonaryhypertension
['FUNDING_OTHER'] · PROVIDENCE VA MEDICAL CENTER · NIH-11051200
This study is looking at how a medication might help people with COPD and pulmonary hypertension breathe better and feel more active, so if you have these conditions, you could be part of this research to see if it makes a difference in your daily life.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PROVIDENCE VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11051200 on ClinicalTrials.gov |
What this research studies
This research focuses on patients with Chronic Obstructive Pulmonary Disease (COPD) who also suffer from pulmonary hypertension, a condition that can worsen breathing difficulties. The study will evaluate the effectiveness of a medication called a PDE5 inhibitor, which may help improve lung function and reduce symptoms like breathlessness. By restoring nitric oxide signaling, the treatment aims to enhance patients' quality of life and physical activity levels. Participants will be monitored for changes in their exercise capacity and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans diagnosed with COPD who also experience pulmonary hypertension.
Not a fit: Patients without COPD or those who do not have pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved breathing and quality of life for patients suffering from COPD and pulmonary hypertension.
How similar studies have performed: Previous studies have shown mixed results with PDE5 inhibitors in COPD patients, indicating that this approach is still being explored for its effectiveness.
Where this research is happening
PROVIDENCE, UNITED STATES
- PROVIDENCE VA MEDICAL CENTER — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROUNDS, SHARON IRENE SMITH — PROVIDENCE VA MEDICAL CENTER
- Study coordinator: ROUNDS, SHARON IRENE SMITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.