Investigating a medication to improve breathing in COPD patients with high blood pressure in the lungs
Official title: Effect of PDE5 inhibitor on respiratory symptoms in COPD complicated by pulmonaryhypertension
Funded at Providence VA Medical Center · NIH-11051200 · Data updated 2026-11-12
This study is looking at how a medication might help people with COPD and pulmonary hypertension breathe better and feel more active, so if you have these conditions, you could be part of this research to see if it makes a difference in your daily life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence VA Medical Center NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| NIH project number | 5I01CX002543-02 |
| Project ID | NIH-11051200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans diagnosed with COPD who also experience pulmonary hypertension.
✕Less likely to help
Patients without COPD or those who do not have pulmonary hypertension may not benefit from this research.
What this research studies
This research focuses on patients with Chronic Obstructive Pulmonary Disease (COPD) who also suffer from pulmonary hypertension, a condition that can worsen breathing difficulties. The study will evaluate the effectiveness of a medication called a PDE5 inhibitor, which may help improve lung function and reduce symptoms like breathlessness. By restoring nitric oxide signaling, the treatment aims to enhance patients' quality of life and physical activity levels. Participants will be monitored for changes in their exercise capacity and overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved breathing and quality of life for patients suffering from COPD and pulmonary hypertension.
How similar studies have gone: Previous studies have shown mixed results with PDE5 inhibitors in COPD patients, indicating that this approach is still being explored for its effectiveness.
Where this research is happening
-
Providence VA Medical Center
Providence, United States Active
Researchers
- Principal investigator: Rounds, Sharon Irene Smith — Providence VA Medical Center
- Study coordinator: Rounds, Sharon Irene Smith
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.