Investigating a genetic variant's role in kidney damage in lupus patients
Official title: The role of human SLE causal variant NCF1.pR90H in promoting kidney damage
Funded at Medical University of South Carolina · NIH-10740630 · Data updated 2026-11-12
This study is looking at how a specific gene change might affect kidney problems in people with lupus, especially those with kidney inflammation, to help us better understand and treat these issues in patients from different backgrounds.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $365,420 |
| NIH project number | 1R21AR081933-01A1 |
| Project ID | NIH-10740630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those experiencing kidney complications.
✕Less likely to help
Patients without a diagnosis of systemic lupus erythematosus or those not experiencing kidney issues may not benefit from this research.
What this research studies
This research focuses on understanding how a specific genetic variant, NCF1.pR90H, contributes to kidney damage in patients with systemic lupus erythematosus (SLE). By examining the relationship between this variant and the severity of kidney issues, particularly lupus nephritis, the study aims to identify mechanisms that lead to inflammation and damage in kidney tissues. The research involves analyzing genetic data and kidney biopsies from diverse patient populations, including Asian and African Americans, to assess the impact of this variant on kidney health. Through this approach, the study seeks to enhance our understanding of SLE and its complications.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and managing kidney damage in lupus patients.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors contributing to autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Tsao, Betty P — Medical University of South Carolina
- Study coordinator: Tsao, Betty P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.