Interactions between specific channels that control blood pressure regulation
Official title: Panx1-PIEZO1 Interactions Regulate Renin Release
Funded at University of Virginia · NIH-10980409 · Data updated 2026-11-12
This study is looking at how two specific proteins in your kidneys work together to control the release of a hormone that helps manage blood pressure, which could lead to new ways to treat high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $717,773 |
| NIH project number | 1R01HL171997-01A1 |
| Project ID | NIH-10980409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension or those at risk of developing high blood pressure.
✕Less likely to help
Patients with normal blood pressure or those not affected by cardiovascular diseases may not benefit from this research.
What this research studies
This research investigates how certain cellular channels, specifically Panx1 and PIEZO1, interact to regulate the release of renin, a key hormone in controlling blood pressure. By examining juxtaglomerular cells in the kidneys, the study aims to understand how mechanical signals and hormonal influences affect renin release. The researchers will explore the role of protein kinase A and estrogen receptors in this process, using novel mouse models to gather data. This could lead to new insights into hypertension and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hypertension, potentially reducing the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in manipulating the renin-angiotensin-aldosterone system for hypertension treatment, suggesting that this approach may also yield significant findings.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Isakson, Brant E — University of Virginia
- Study coordinator: Isakson, Brant E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.