Integrating depression treatment into tuberculosis care in South Africa

The Effectiveness and Cost-Effectiveness of Implementing Evidence-Based Depression Treatment within the TB Care Platform in South Africa: A Hybrid Effectiveness-Implementation Trial

NIH-funded research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-10494127

This study is looking at how to combine short counseling sessions for depression with tuberculosis treatment in South Africa, aiming to help people who have both conditions feel better and save on treatment costs.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNew York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10494127 on NIH RePORTER

What this research studies

This research investigates how to effectively integrate interpersonal counseling, a brief psychological intervention for major depressive disorder (MDD), into the tuberculosis (TB) care platform in South Africa. By focusing on patients who are co-infected with TB and MDD, the study aims to improve health outcomes and reduce the costs associated with TB treatment. The approach involves a hybrid effectiveness-implementation trial conducted in eight clinics, targeting approximately 1,410 individuals. The goal is to assess both the effectiveness and cost-effectiveness of this integration to enhance patient care.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals in South Africa who are diagnosed with both tuberculosis and major depressive disorder.

Not a fit: Patients who do not have tuberculosis or major depressive disorder may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve the treatment outcomes for patients suffering from both tuberculosis and depression.

How similar studies have performed: Previous research has shown success in integrating mental health interventions into primary care settings, making this approach promising.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Mental disordersMental health disordersPsychiatric DiseasePsychiatric Disorderpsychological disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.