Inhibiting a specific enzyme to treat chronic bladder pain
PNPase inhibition as an effective treatment for chronic bladder pain
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10580923
This study is looking at how blocking a specific enzyme might help relieve chronic bladder pain for people with interstitial cystitis/bladder pain syndrome, especially since stress can make the pain worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10580923 on ClinicalTrials.gov |
What this research studies
This research investigates the potential of inhibiting PNPase, an enzyme, as a treatment for chronic bladder pain, specifically interstitial cystitis/bladder pain syndrome (IC/BPS). The study aims to understand the mechanisms behind this painful condition, which is often exacerbated by psychological and oxidative stress. By exploring how chronic stress affects pain perception and bladder function, the researchers hope to identify new therapeutic targets that could lead to more effective treatments for patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with interstitial cystitis/bladder pain syndrome who experience chronic pain and urinary frequency.
Not a fit: Patients with bladder pain caused by identifiable infections or structural abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new and effective treatment option for patients suffering from chronic bladder pain.
How similar studies have performed: While chronic bladder pain is a challenging area with limited effective treatments, this approach is novel and aims to explore untested mechanisms in pain management.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIRDER, LORI A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: BIRDER, LORI A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Disease, acute disease/disorder, acute disorder, Chronic Disease