Inflammation in the brain affects breathing patterns
Official title: Neuroinflammation disrupts cardio-respiratory circuits and patterns
Funded at Louis Stokes Cleveland VA Medical Center · NIH-10806351 · Data updated 2026-11-12
This study looks at how inflammation in the brain affects breathing, especially during serious conditions like sepsis and lung injuries, to help us understand and improve breathing problems that can come with these health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006128-01A2 |
| Project ID | NIH-10806351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing respiratory issues related to systemic infections or lung injuries.
✕Less likely to help
Patients with respiratory conditions not linked to inflammation or those with chronic respiratory diseases may not benefit from this research.
What this research studies
This research investigates how inflammation in the central nervous system impacts the control of breathing, particularly in conditions like sepsis and lung injury. By studying the brainstem's response to inflammation, the researchers aim to understand how it alters respiratory network function and affects breathing patterns. The study involves animal models to explore the relationship between neuro-inflammation and changes in respiratory control, focusing on specific brain regions that regulate breathing. The findings could provide insights into how to better manage respiratory issues related to systemic infections and lung injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from respiratory complications due to inflammation.
How similar studies have gone: Previous research has shown that understanding neuro-inflammation can lead to significant advancements in treating respiratory dysfunctions, indicating a promising avenue for this study.
Where this research is happening
-
Louis Stokes Cleveland VA Medical Center
Cleveland, United States Active
Researchers
- Principal investigator: Jacono, Frank Joseph — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Jacono, Frank Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.