Improving ventilation strategies to reduce lung injury in critically ill patients
Official title: 2/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)
Funded at Beth Israel Deaconess Medical Center · NIH-10912795 · Data updated 2026-11-12
This study is looking at a new way to help people with severe breathing problems who need a machine to help them breathe, to see if adjusting the machine settings can make them feel better and recover faster compared to the usual care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $661,149 |
| NIH project number | 5U24HL166784-02 |
| Project ID | NIH-10912795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with moderate to severe ARDS and require mechanical ventilation.
✕Less likely to help
Patients who are not critically ill or do not require mechanical ventilation for respiratory distress may not benefit from this research.
What this research studies
This research focuses on enhancing ventilation techniques for patients suffering from acute respiratory distress syndrome (ARDS), particularly those requiring mechanical ventilation. It aims to implement a precise method of adjusting ventilator settings to minimize lung injury caused by overdistension and collapse. By conducting a multicenter trial, the research will compare this new ventilation strategy against standard care to evaluate its effectiveness in reducing mortality rates. Patients will be monitored closely to assess the impact of these ventilation adjustments on their recovery.
Why it matters
Potential benefit: If successful, this research could significantly lower the risk of death for patients with moderate to severe ARDS by improving ventilation methods.
How similar studies have gone: Previous research has shown promise in improving patient outcomes with similar ventilation strategies, indicating potential for success in this approach.
Where this research is happening
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Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Baedorf Kassis, Elias — Beth Israel Deaconess Medical Center
- Study coordinator: Baedorf Kassis, Elias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.