Improving treatments for type 1 diabetes through better cell transplantation methods
Official title: Optimized bone marrow conditioning and tolerance assays to advance cell-based therapies for diabetes
Funded at Stanford University · NIH-10999248 · Data updated 2026-11-12
This study is looking for safer ways to transplant insulin-producing cells to help kids and teens with type 1 diabetes, using a method that helps their bodies accept the new cells without the harsh side effects of traditional treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32DK141209-01 |
| Project ID | NIH-10999248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with type 1 diabetes who may benefit from cell-based therapies.
✕Less likely to help
Patients with type 2 diabetes or those who do not have type 1 diabetes may not receive any benefit from this research.
What this research studies
This research focuses on developing safer and more effective methods for transplanting insulin-producing cells to treat type 1 diabetes, particularly in young children and adolescents. It aims to create a non-toxic approach to prevent the immune system from rejecting these transplanted cells, which is a major barrier to successful treatment. The study will explore mixed chimerism, a technique that could help the body accept donor tissues without the harmful effects of traditional conditioning methods like radiation or chemotherapy. By finding a reliable source of donor cells and improving tolerance, this research could significantly enhance treatment options for patients with type 1 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatments for type 1 diabetes, reducing the burden of daily insulin administration for patients.
How similar studies have gone: Previous research has shown promise in using mixed chimerism for transplant tolerance, indicating that this approach could be a viable option for improving diabetes treatment.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Ramos, Stephan Anthony — Stanford University
- Study coordinator: Ramos, Stephan Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.