Improving Treatment Monitoring for Early Psoriatic Arthritis
Official title: Precision Monitoring of Treatment Response in Early Psoriatic Arthritis: Integrating at-Home RNA Microsampling into Ongoing, Remote, Smart Phone-Based, Digital Data Capturing
Funded at New York University School of Medicine · NIH-11113855 · Data updated 2026-11-12
This project aims to find better ways to track how well treatments work for people with early psoriatic arthritis by using at-home RNA samples and smartphone data.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $373,686 |
| NIH project number | 5R01AR084274-02 |
| Project ID | NIH-11113855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this type of research would be adults aged 21 and older who have been diagnosed with early psoriatic arthritis.
✕Less likely to help
Patients without psoriatic arthritis or those not receiving treatments for the condition would not directly benefit from this specific monitoring approach.
What this research studies
Many people with psoriatic arthritis don't respond well to common treatments like TNF inhibitors, and doctors don't always know why. This project wants to change that by using a new approach that combines small RNA samples collected at home with digital information gathered through smartphones. Researchers will use advanced computer methods to look for patterns in this data, hoping to understand why some treatments work for certain individuals and others don't. The goal is to develop a more personalized way to monitor treatment effectiveness, right from your own home.
Why it matters
Potential benefit: If successful, this work could lead to more precise and personalized treatment plans for psoriatic arthritis, helping patients find the right therapy faster and avoid ineffective medications.
How similar studies have gone: While current treatments have improved outcomes for many, this approach uses novel at-home monitoring and machine learning to address the significant challenge of treatment non-response, building on existing knowledge of disease pathogenesis.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Scher, Jose U. — New York University School of Medicine
- Study coordinator: Scher, Jose U.
Related research
Other NIH-funded projects on the same topics.
-
Precision monitoring of Psoriatic Arthritis treatment using at-home RNA sampling and smartphone data
A new study will track how Psoriatic Arthritis patients respond to TNF-inhibitor therapy using at-home RNA sampling and a remote smartphone app to collect data.
-
Spine inflammation in psoriatic arthritis
We will use a new total-body PET/CT scan with an FDG tracer to find and measure spinal inflammation in people with psoriatic arthritis that affects the spine.
-
Investigating how IL-17A contributes to psoriatic arthritis
This study is looking at how a protein called IL-17A contributes to psoriatic arthritis, which causes joint pain and inflammation, using a special animal model to find new ways to help people with this condition feel better.
-
Understanding the causes of ongoing joint pain in people with psoriatic arthritis
This study is looking at what causes ongoing joint pain in people with psoriatic arthritis, using special imaging techniques to better understand both the physical and emotional aspects of pain, with the goal of finding better ways to help manage it.
-
Understanding spinal inflammation in axial psoriatic arthritis
This study is looking at how inflammation affects the spine in people with axial psoriatic arthritis, using special imaging techniques to get a clearer picture of what's happening, which could help doctors diagnose and treat this condition better.
-
Understanding how different traits and genes affect treatment responses in psoriatic arthritis
This study is looking at how different traits and genes in people with psoriatic arthritis can affect how well treatments work for them, so we can find better, personalized options for managing their condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.