Improving treatment for glioblastoma using nanotechnology and thermal therapy
Official title: Nanotherapeutic enhancement of interstitial thermal therapy for glioblastoma
Funded at University of Maryland Baltimore · NIH-10988245 · Data updated 2026-11-12
This study is looking at new ways to make heat treatment for glioblastoma, a tough type of brain tumor, work better by using special tools and techniques to help deliver medicine more effectively, and it invites patients to join trials to see how these exciting new methods can improve their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $634,796 |
| NIH project number | 5R01CA269995-03 |
| Project ID | NIH-10988245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma who have limited treatment options due to the aggressive nature of the disease.
✕Less likely to help
Patients with other types of brain tumors or those who are not eligible for thermal therapy may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of thermal therapy for glioblastoma, a highly aggressive brain tumor. By utilizing advanced techniques like MRI-guided laser probes, the study aims to improve drug delivery and treatment outcomes for patients with this challenging condition. The approach involves using nanotherapeutics to sensitize tumors to radiation, potentially increasing the efficacy of existing treatments. Patients may be involved in clinical trials that explore these innovative therapies and their effects on tumor response.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients with glioblastoma.
How similar studies have gone: Preliminary results from similar approaches using laser interstitial thermal therapy have shown promise, indicating potential for success in this novel application.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Woodworth, Graeme F — University of Maryland Baltimore
- Study coordinator: Woodworth, Graeme F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.