Improving transplant survival for cell therapies using bio-integrated devices
Official title: Development of bio-integrated devices to enhance transplant survival for subcutaneous encapsulated cell therapies
Funded at Stanford University · NIH-11253032 · Data updated 2026-11-12
This study is working on new devices that help transplanted cells survive better by improving oxygen levels where they're placed, making it easier to treat conditions like autoimmune diseases and cancers with less invasive procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,645 |
| NIH project number | 4R00EB032427-03 |
| Project ID | NIH-11253032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from autoimmune disorders or cancers who may benefit from cell therapy.
✕Less likely to help
Patients with conditions that do not involve the need for cell therapies or those who are not suitable candidates for transplantation may not benefit from this research.
What this research studies
This research focuses on enhancing the survival of transplanted cells used in encapsulated cell therapies (ECT) by developing bio-integrated devices. These devices aim to improve the oxygen levels in the microenvironment where the cells are implanted, which is crucial for their survival and function. The approach involves advanced microfabrication techniques and bioelectronics to create devices that can be implanted subcutaneously, allowing for minimally invasive procedures. By addressing challenges such as low vascularization and fibrosis, this research seeks to make ECT a viable treatment option for various conditions, including autoimmune diseases and cancers.
Why it matters
Potential benefit: If successful, this research could lead to more effective and reliable treatments for patients with conditions that currently require complex drug regimens.
How similar studies have gone: Other research has shown promise in using bio-integrated devices to enhance cell therapy outcomes, indicating a potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Krishnan, Siddharth — Stanford University
- Study coordinator: Krishnan, Siddharth
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.