Improving tests that measure substances in samples for better accuracy
Official title: Improving the analysis and use of contaminated immunoassays: from methods development to implementation
Funded at Columbia University Health Sciences · NIH-10981258 · Data updated 2026-11-12
This study is working on improving tests that measure substances in samples, like blood, by creating a new method that helps make the results more accurate and reliable, so people can trust the information they get from these tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $407,998 |
| NIH project number | 1R01ES035784-01A1 |
| Project ID | NIH-10981258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who may be affected by allergies or asthma.
✕Less likely to help
Patients outside the age range of 0-11 years or those without allergies or asthma may not benefit from this research.
What this research studies
This research focuses on enhancing immunoassays, which are tests that measure the concentration of substances in samples using antibody-antigen reactions. The current methods have significant limitations, including measurement errors and difficulties in estimating concentrations accurately. The project aims to develop a new Bayesian workflow that addresses these issues by accounting for potential errors and contamination in samples. This will involve creating a step-by-step guide for model building and validation, ultimately improving the reliability of immunoassay results.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostic tests for conditions like asthma and allergies in children.
How similar studies have gone: Other research has shown promise in using Bayesian methods for improving diagnostic tests, indicating potential success for this approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Chen, Qixuan — Columbia University Health Sciences
- Study coordinator: Chen, Qixuan
Related research
Other NIH-funded projects on the same topics.
-
Precision phenotyping of emphysema in the elderly: a study in diverse adults
Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.
-
HPV-based cervical cancer screening and treatment implementation in resource-limited settings
A collaborative project to help doctors in South Africa put HPV-based screening and same-day treatment for cervical cancer into routine care, so more people get fast, effective care.
-
Cervical cancer screening and treatment rollout in resource-poor settings
A team from Columbia and the University of Cape Town is testing how to best implement affordable, same-day HPV-based screen-and-treat for cervical cancer in public health settings.
-
Understanding SCN3A-related Developmental Epileptic Encephalopathy and Finding Better Treatments
This NIH grant focuses on how SCN3A gene variants cause developmental epileptic encephalopathy and aims to develop more effective therapies for affected patients.
-
mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
-
M-CaRE: Mobile clinics and a smart heart-lung care tool for multimorbidity
A mobile, multilingual tool plus community health workers will help screen and manage high blood pressure and COPD in diverse adult patients, especially in underserved areas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.