Improving techniques to analyze proteins in human cells
Advancing top-down proteomics with capillary electrophoresis-mass spectrometry
This study is exploring new ways to look at proteins in individual human cells to find important clues about how cancer spreads and how our bodies develop, which could help improve tests and treatments for patients with colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11080248 on NIH RePORTER |
What this research studies
This research focuses on developing advanced techniques using capillary electrophoresis-mass spectrometry (CE-MS) to analyze proteins in human cells. By enhancing the ability to identify and characterize proteins at a single-cell level, the research aims to uncover important biological information related to developmental processes and cancer. Specifically, it seeks to identify new biomarkers for colorectal cancer metastasis and understand protein roles during early embryonic development. Patients may benefit from insights gained through this research, which could lead to improved diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer or those interested in the biological mechanisms of cancer and development.
Not a fit: Patients with conditions unrelated to cancer or developmental biology may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new biomarkers for colorectal cancer, improving early detection and treatment options for patients.
How similar studies have performed: Other research has shown success in using advanced proteomics techniques to identify biomarkers, suggesting that this approach has the potential for significant findings.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Sun, Liangliang — Michigan State University
- Study coordinator: Sun, Liangliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.