Improving techniques to analyze proteins in human cells
Official title: Advancing top-down proteomics with capillary electrophoresis-mass spectrometry
Funded at Michigan State University · NIH-11080248 · Data updated 2026-11-12
This study is exploring new ways to look at proteins in individual human cells to find important clues about how cancer spreads and how our bodies develop, which could help improve tests and treatments for patients with colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $400,534 |
| NIH project number | 5R35GM153479-02 |
| Project ID | NIH-11080248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer or those interested in the biological mechanisms of cancer and development.
✕Less likely to help
Patients with conditions unrelated to cancer or developmental biology may not receive direct benefits from this research.
What this research studies
This research focuses on developing advanced techniques using capillary electrophoresis-mass spectrometry (CE-MS) to analyze proteins in human cells. By enhancing the ability to identify and characterize proteins at a single-cell level, the research aims to uncover important biological information related to developmental processes and cancer. Specifically, it seeks to identify new biomarkers for colorectal cancer metastasis and understand protein roles during early embryonic development. Patients may benefit from insights gained through this research, which could lead to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new biomarkers for colorectal cancer, improving early detection and treatment options for patients.
How similar studies have gone: Other research has shown success in using advanced proteomics techniques to identify biomarkers, suggesting that this approach has the potential for significant findings.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Sun, Liangliang — Michigan State University
- Study coordinator: Sun, Liangliang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.