Improving T-cell Therapy for Children with Brain Cancer
Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy
This project aims to create a more precise T-cell therapy to better fight brain tumors in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11167572 on NIH RePORTER |
What this research studies
We are working to improve a special type of immune therapy called adoptive T-cell therapy for children with aggressive brain cancers. Our previous work showed that a first version of this therapy was safe and showed early promise in treating these cancers. Now, we are developing a "next-generation" approach that uses a patient's unique tumor information to create T cells that can target many different parts of their cancer. This new method helps overcome the challenge of tumors having different types of cells, making the treatment more effective.
Who could benefit from this research
Good fit: Ideal candidates would be children affected by high-grade glioma or other invasive and refractory brain cancers, particularly those who might benefit from advanced immune therapies.
Not a fit: Patients whose tumors do not respond to T-cell therapies or those with very rapidly progressing disease might not receive benefit from this specific approach.
Why it matters
Potential benefit: If successful, this advanced therapy could offer children with high-grade gliomas a more effective and lasting treatment option.
How similar studies have performed: A "first-generation" version of this therapy has already shown promising pre-clinical and early clinical efficacy, including prolonged remission in some patients.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Mitchell, Duane a. — University of Florida
- Study coordinator: Mitchell, Duane a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.