Improving T Cell Function to Fight HIV
Modulating T Cell Activation to Combat HIV Persistence
This study is looking at how to make T cells, which help fight HIV, work better in people on HIV medication, with the hope of finding new treatments that could reduce or even eliminate the need for lifelong therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10948156 on NIH RePORTER |
What this research studies
This research focuses on understanding and enhancing the function of T cells, which are crucial for fighting HIV. It aims to identify the molecular pathways that affect T cell sensitivity to HIV antigens, particularly in patients who are on antiretroviral therapy. By exploring how T cells can be better activated and how they interact with other immune cells, the research seeks to develop new therapies that could potentially eliminate the need for lifelong medication in people living with HIV. The approach includes examining the mechanisms that lead to T cell dysfunction and finding ways to modulate these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and are interested in new treatment options.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that allow people with HIV to control the virus without continuous medication.
How similar studies have performed: Previous research has shown promise in enhancing T cell responses in HIV, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Collins, David Randolph — Massachusetts General Hospital
- Study coordinator: Collins, David Randolph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.