Improving social connections by targeting dopamine responses

Targeting Dopamine-Mediated Social Reward Sensitivity to Remediate Social Disconnection

NIH-funded research University of California, San Diego · NIH-10812510

This study is looking at whether boosting the brain's dopamine levels can help people with anxiety and depression feel more excited about social interactions, making it easier for them to connect with others.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-10812510 on NIH RePORTER

What this research studies

This research investigates how enhancing the dopamine system can improve social reward sensitivity in individuals suffering from anxiety and depression. By pharmacologically modulating dopamine levels, the study aims to increase anticipation of social rewards, which may lead to better social connections. The approach involves a two-phase project that tests the effects of these interventions on social connectedness in patients with clinical anxiety or depression. Participants will be monitored for changes in their motivation and behavior towards social interactions.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals experiencing clinical levels of anxiety or depression who struggle with social disconnection.

Not a fit: Patients who do not have anxiety or depression, or those who are not experiencing social disconnection, may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new treatments that significantly improve social connections for patients with anxiety and depression.

How similar studies have performed: Previous research has indicated that targeting the dopamine system can influence social behavior, suggesting potential success for this approach.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Anxiety Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.