Improving sepsis outcomes for veterans using a learning healthcare system
Official title: Building a Learning Healthcare System to Understand and Improve Sepsis Outcomes in the VA TeleICU Network
Funded at Iowa City VA Medical Center · NIH-11127373 · Data updated 2026-11-12
This study is looking at how to improve the treatment of sepsis in veterans by using a special remote monitoring system to understand what helps some patients do better than others, with the hope of finding ways to provide more personalized care and improve survival rates.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2020 |
| Project end | September 30, 2024 |
| Funding year | 2025 |
| NIH project number | 5I01HX002950-06 |
| Project ID | NIH-11127373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have been diagnosed with sepsis or are at risk of developing it.
✕Less likely to help
Patients who do not have sepsis or are not veterans may not receive any benefit from this research.
What this research studies
This research aims to enhance the understanding and treatment of sepsis, a severe infection response affecting many veterans. By utilizing a TeleICU system, the project will analyze patient data to identify factors that contribute to better or worse outcomes in sepsis cases. The goal is to improve healthcare quality and safety by addressing gaps in current knowledge about effective interventions and patient characteristics. This approach will help tailor treatments to individual needs, potentially leading to better survival rates.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better treatment strategies for veterans suffering from sepsis.
How similar studies have gone: Previous research has shown that utilizing data-driven approaches in healthcare can lead to significant improvements in patient outcomes, suggesting this method may be effective.
Where this research is happening
-
Iowa City VA Medical Center
Iowa City, United States Active
Researchers
- Principal investigator: Blum, James Marlow — Iowa City VA Medical Center
- Study coordinator: Blum, James Marlow
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.