Improving remote health measurements for patients with primary ciliary dyskinesia
Official title: Clinical Trial Readiness - Primary Ciliary Dyskinesia (CTR-PCD)
Funded at Seattle Children's Hospital · NIH-10656216 · Data updated 2026-11-12
This study is looking to make it easier and more reliable for people with primary ciliary dyskinesia (PCD) to take health measurements from home, so they can join clinical trials without having to travel far, and it could also help others with chronic lung diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $169,427 |
| NIH project number | 5R21TR004057-02 |
| Project ID | NIH-10656216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary ciliary dyskinesia, particularly those who may have difficulty accessing traditional clinical trial settings.
✕Less likely to help
Patients without a diagnosis of primary ciliary dyskinesia or those who do not experience respiratory issues may not benefit from this research.
What this research studies
This research focuses on enhancing the quality and reliability of mobile health measurements for respiratory endpoints in patients with primary ciliary dyskinesia (PCD). By establishing optimal conditions for these measurements, the project aims to facilitate participation in clinical trials, especially for patients who may live far from research centers. The approach leverages remote monitoring to improve access and potentially reduce the number of participants needed for future studies. The findings will not only benefit PCD clinical trials but also have implications for other chronic lung diseases.
Why it matters
Potential benefit: If successful, this research could lead to more accessible and efficient clinical trials for patients with primary ciliary dyskinesia.
How similar studies have gone: Other research has shown success with remote monitoring approaches in chronic lung diseases, indicating a promising avenue for this study.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Rosenfeld, Margaret — Seattle Children's Hospital
- Study coordinator: Rosenfeld, Margaret
Related research
Other NIH-funded projects on the same topics.
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Personalized therapeutic oligonucleotides for primary ciliary dyskinesia
A new therapy approach uses customized RNA-based medicines to help people with Primary Ciliary Dyskinesia, a rare lung condition, by correcting how genes are read in airway cells.
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Pathogenesis and New Treatments for Primary Ciliary Dyskinesia (PCD)
Researchers are studying why Primary Ciliary Dyskinesia causes lung and airway problems and how to develop better treatments for people with this condition.
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New genes behind primary ciliary dyskinesia
This project looks for new genes that cause primary ciliary dyskinesia to help people with chronic respiratory infections and related complications.
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How a lung cell protein (cytoglobin) affects cilia movement and organ placement
Researchers are looking at whether the airway protein cytoglobin controls nitric oxide and cilia motion in ways that could explain primary ciliary dyskinesia and situs inversus.
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Understanding and treating Primary Ciliary Dyskinesia
This study is looking at a pig model of Primary Ciliary Dyskinesia (PCD) to better understand how the condition affects breathing and to find new ways to help improve the lives of people living with PCD.
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Finding new genes that cause primary ciliary dyskinesia
This study is looking for new genes that cause primary ciliary dyskinesia (PCD), a condition that affects breathing, to help make faster and cheaper tests for it, using a special model from frog embryos to learn more about how cilia work.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.