Improving recovery from Acute Respiratory Distress Syndrome by targeting a specific enzyme
Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier Recovery
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11057632
This study is looking at how a special enzyme called caspase 3 helps heal blood vessels in people with Acute Respiratory Distress Syndrome (ARDS), with the hope of finding new ways to improve treatments and support recovery for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11057632 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific enzyme, caspase 3, plays different roles in the recovery of blood vessel barriers in patients suffering from Acute Respiratory Distress Syndrome (ARDS). The team will investigate how this enzyme can be manipulated to promote healing and restore function to damaged endothelial cells, which are crucial for maintaining proper blood vessel integrity. By exploring the balance between cell death and recovery signals, the research aims to identify new therapeutic targets that could enhance recovery from ARDS. Patients may benefit from insights that lead to improved treatments for this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Acute Respiratory Distress Syndrome.
Not a fit: Patients with chronic respiratory conditions unrelated to ARDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery rates and outcomes for patients with ARDS.
How similar studies have performed: Previous research has shown promising results in targeting apoptotic pathways for therapeutic benefits, suggesting potential success for this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAMARLA, MAHENDRA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DAMARLA, MAHENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome