NIH-funded research NIH-funded research

Improving patient access to gynecologic cancer trials at UVA

Official title: Enhancing accrual across gynecologic and solid tumor trials

Funded at University of Virginia · NIH-11395537 · Data updated 2026-11-12

This grant helps UVA boost enrollment in gynecologic and solid tumor trials so more women with gynecologic cancers can access cutting-edge therapies.

More Solid Tumor research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Virginia
NIH-funded
Lab location1 site (Charlottesville, United States)
Project startSeptember 1, 2024
Project endAugust 31, 2029
Funding year2026
Award (this year)$135,573
NIH project number5R50CA285360-03
Project IDNIH-11395537 on NIH RePORTER

Who could benefit from this research

Could help

Women with gynecologic cancers treated or seeking care at the UVA Comprehensive Cancer Center who may be eligible for clinical trials.

Less likely to help

Patients not currently eligible for trials or not interested in trial participation may not benefit.

What this research studies

The grant supports dedicating time to enhance clinical trial participation by removing barriers for patients and providers. It aims to grow participation in NCTN/ETCTN trials and strengthen UVA leadership in new studies. The effort includes building clinical research infrastructure and mentoring translational teams to accelerate trial availability for patients. It focuses on expanding accrual depth and breadth while maintaining high-quality care.

Why it matters

Potential benefit: Patients could gain faster access to new treatments and improved care through more available trials.

How similar studies have gone: Similar programs have shown that targeted trial-access initiatives can increase enrollment and access to experimental therapies.

Where this research is happening

  • University of Virginia
    Charlottesville, United States
    Active

Researchers

  • Principal investigator: Duska, Linda R — University of Virginia
  • Study coordinator: Duska, Linda R

Related research

Other NIH-funded projects on the same topics.

  • Dual-targeted DOTA CAR T cells with image-guided monitoring for solid tumors

    A Penn team is developing a controllable CAR T cell therapy for solid tumors that can be tracked with PET imaging and guided by targeted agents to improve safety and effectiveness.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11457469

  • Tuning CAR T cells to work better in solid tumors

    A cancer-immunotherapy approach uses specially trained CAR T cells designed to attack solid tumors more effectively and safely.

    NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11384863

  • A 3D lab tool to see how solid tumors squeeze and spread

    This project builds a tiny 3D device that measures how solid tumors push, deform, and let cancer cells break away, which could help people with cancers that form solid tumors.

    NIH research Cornell University · Ithaca, United States · NIH-11286769

  • Dual-target CAR T therapy with PET tracking for solid tumors

    A controllable CAR T-cell treatment that doctors can track with PET scans and direct at solid tumors in adults whose cancers express folate receptors.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11189714

  • Atlas of the tumor environment in childhood cancers

    This project will map the cells and signals surrounding childhood solid tumors like neuroblastoma, rhabdomyosarcoma, and Wilms tumor to find weaknesses that could help children with high-risk disease.

    NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11180224

  • KITv-enhanced CAR T cells for mesothelin-positive solid tumors

    This work develops engineered CAR T cells that use a KITv switch to help treat people with mesothelin-expressing solid tumors, including pleural cancers.

    NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11168905

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.