Improving outcomes of epilepsy surgery using brain connectivity analysis
Development of multimodal network analyses to improve epilepsy surgery outcomes
This study is looking to help people with epilepsy who haven't found relief from medications by using advanced brain imaging and technology to pinpoint the exact areas in the brain causing their seizures, which could lead to better surgery outcomes and a happier, seizure-free life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10995273 on NIH RePORTER |
What this research studies
This research focuses on enhancing the success of epilepsy surgery for patients with drug-resistant focal epilepsy by accurately identifying the regions of the brain responsible for seizures. It employs advanced techniques such as structural and functional MRI, along with machine learning, to analyze brain connectivity patterns. By integrating these innovative methods, the study aims to better localize epileptogenic zones, which are critical for effective surgical intervention. Patients may benefit from more precise surgical planning, potentially leading to reduced seizures and improved quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with drug-resistant focal epilepsy who are considering surgery.
Not a fit: Patients with epilepsy that is well-controlled by medication or those who do not qualify for surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve surgical outcomes for epilepsy patients, potentially reducing or eliminating seizures.
How similar studies have performed: Previous research has shown promise in using brain connectivity analysis to improve surgical outcomes in epilepsy, indicating that this approach may be effective.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Englot, Dario J — Vanderbilt University Medical Center
- Study coordinator: Englot, Dario J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.