Improving outcomes in sepsis caused by Gram-negative bacteria using targeted nanotherapeutics
Official title: Targeting Both Hyperinflammation and Pyroptosis Via Nanotherapeutics to Improve Outcomes in Gram-Negative Sepsis
Funded at Upstate Medical University · NIH-10998520 · Data updated 2026-11-12
This study is testing a new treatment using tiny particles to help people with sepsis, a serious condition caused by infections, by reducing harmful inflammation and improving their immune response to help them recover better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | July 18, 2024 |
| Project end | July 17, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30GM153101-01A1 |
| Project ID | NIH-10998520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis caused by Gram-negative bacterial infections.
✕Less likely to help
Patients with sepsis caused by Gram-positive bacteria or other non-bacterial infections may not benefit from this research.
What this research studies
This research focuses on sepsis, a severe condition caused by infections that leads to an uncontrolled immune response. The study aims to develop a new treatment using nanoparticles that can target both the excessive inflammation and cell death associated with sepsis. By using innovative immune-modulating nanoparticles, the research seeks to reduce the harmful effects of a cytokine storm and improve the immune response in patients suffering from Gram-negative bacterial infections. This approach is designed to enhance patient recovery and prevent long-term complications.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that significantly improves recovery outcomes for patients with sepsis.
How similar studies have gone: While the approach of using nanoparticles for immune modulation is innovative, similar strategies targeting inflammation in sepsis have shown promise in preliminary studies.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Messina, Jennifer M — Upstate Medical University
- Study coordinator: Messina, Jennifer M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.