Improving outcomes in newborns with E. coli infections by targeting iron levels
Targeting iron to improve outcomes in neonatal Escherichia coli sepsis
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10762957
This study is looking at how adjusting iron levels might help newborns with early onset sepsis from E. coli fight infections better, with the hope of finding new ways to improve their health and reduce the need for antibiotics.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10762957 on ClinicalTrials.gov |
What this research studies
This research investigates how targeting iron levels can improve outcomes for newborns suffering from early onset sepsis caused by E. coli. The study aims to understand the role of iron in the immune response of neonates and how it can be manipulated to enhance their ability to fight infections. By exploring immune cell functions and the effects of iron on these cells, the research seeks to identify new therapeutic strategies that could reduce the reliance on antibiotics and improve survival rates. The approach includes both laboratory studies and potential clinical applications to better manage infections in critically ill newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns, particularly those at risk of early onset sepsis due to E. coli infections.
Not a fit: Patients who are not newborns or those who do not have early onset sepsis caused by E. coli may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced complications for newborns with E. coli infections.
How similar studies have performed: Other research has shown promising results in targeting immune responses in neonatal infections, suggesting that this approach may yield significant advancements.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERMICK, JENNIFER — UNIVERSITY OF IOWA
- Study coordinator: BERMICK, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autoimmune disorder, autoimmunity disease, Autoimmune Diseases